Preferred Label : Culmerciclib;
NCIt synonyms : CDK4/6 Inhibitor TQB3616;
NCIt definition : An orally bioavailable, selective inhibitor of cyclin-dependent kinase (CDK) types
4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration,
culmerciclib selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation
of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S-phase
transition and leads to cell cycle arrest. This suppresses DNA replication and decreases
tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated
in many tumor cell types and play a key role in the regulation of both cell cycle
progression from the G1-phase into the S-phase and tumor cell proliferation.;
UNII : ZU5GL4E4WH;
CAS number : 2004705-28-4;
Molecule name : TQB 3616; TQB-3616;
NCI Metathesaurus CUI : CL1921935;
Origin ID : C203166;
UMLS CUI : C5909046;
Semantic type(s)
- concept_is_in_subset
- has_target
