Preferred Label : CDK4/6 Inhibitor GLR2007;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and
6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK4/6
inhibitor GLR2007 selectively targets and inhibits CDK4 and CDK6, which inhibits the
phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated
G1-S-phase transition and leads to cell cycle arrest. This suppresses DNA replication
and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that
are upregulated in many tumor cell types and play a key role in the regulation of
both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation.;
Molecule name : GLR-2007; GLR 2007;
NCI Metathesaurus CUI : CL1642368;
Origin ID : C176509;
UMLS CUI : C5447282;
Semantic type(s)
- concept_is_in_subset
- has_target
