Preferred Label : Fovinaciclib;
NCIt synonyms : Cyclin-dependent Kinase 4/6 Inhibitor FCN-437; FCN-437c; CDK4/6 Inhibitor FCN-437;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and
6 (CDK6), with potential antineoplastic activity. Upon administration, fovinaciclib
selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma
protein (Rb) early in the G1 phase, prevents CDK-mediated G1/S transition and leads
to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation.
CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types
and play key roles in the regulation of both cell cycle progression from the G1-phase
into the S-phase and cell proliferation.;
UNII : LPW3H579X8;
CAS number : 2146171-49-3;
Molecule name : FCN-437; FCN 437;
NCI Metathesaurus CUI : CL978411;
Origin ID : C165199;
UMLS CUI : C5236977;
Semantic type(s)
- concept_is_in_subset
- has_target
