Preferred Label : CDK4/6 Inhibitor FCN-437;
NCIt synonyms : Cyclin-dependent Kinase 4/6 Inhibitor FCN-437; FCN-437c;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and
6 (CDK6), with potential antineoplastic activity. Upon administration, CDK4/6 inhibitor
FCN-437 selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of
retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1/S transition
and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor
cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in
many tumor cell types and play key roles in the regulation of both cell cycle progression
from the G1-phase into the S-phase and cell proliferation.;
Molecule name : FCN-437; FCN 437;
NCI Metathesaurus CUI : CL978411;
Origin ID : C165199;
UMLS CUI : C5236977;
Semantic type(s)
- concept_is_in_subset
- has_target
