Dalpiciclib - CISMeF

Preferred Label : Dalpiciclib;

NCIt synonyms : CDK4/6 Inhibitor SHR6390;

NCIt definition : A cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Upon administration, dalpiciclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6). This inhibits retinoblastoma (Rb) protein phosphorylation early in the G1 phase, which prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.;

UNII : 5ZHA5P4PFX;

InChIKey : SGJLSPUSUBJWHO-UHFFFAOYSA-N;

CAS number : 1637781-04-4;

Molecule name : SHR-6390; SHR 6390;

NCI Metathesaurus CUI : CL504548;

Codes from synonyms : 59131;

Details

Origin ID

C125899;

UMLS CUI

C5446300;

Currated CISMeF NLP mapping
- dalpiciclib [MeSH concept]
- dalpiciclib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dalpiciclib [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]

Keyword's position in hierarchy(ies) :

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