" /> Dalpiciclib Isethionate - CISMeF





Preferred Label : Dalpiciclib Isethionate;

NCIt definition : The isethionate salt form of dalpiciclib, an orally bioavailable cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Upon oral administration, dalpiciclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6). This inhibits retinoblastoma (Rb) protein phosphorylation early in the G1 phase, which prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.;

UNII : 24DCK9FQ92;

CAS number : 1980822-14-7;

NCI Metathesaurus CUI : CL1927627;

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29/07/2025


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