Preferred Label : Lerociclib;
NCIt synonyms : G1T38 Free Base; 7',8'-Dihydro-2'-((5-(4-(1-methylethyl)-1-piperazinyl)-2-pyridinyl)amino)spiro(cyclohexane-1,9'(6'H)-pyrazino(1',2':1,5)pyrrolo(2,3-d)pyrimidin)-6'-one; CDK4/6 Inhibitor G1T38;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and
6 (CDK6), with potential antineoplastic activity. Upon administration, lerociclib
selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma
protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S phase transition and
leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell
proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many
tumor cell types and play a key role in the regulation of both cell cycle progression
from the G1-phase into the S-phase and tumor cell proliferation.;
UNII : WBH8AY6ENB;
InChIKey : YPJRHEKCFKOVRT-UHFFFAOYSA-N;
CAS number : 1628256-23-4;
Molecule name : G1T38; GB-491; GB 491;
NCI Metathesaurus CUI : CL525730;
Origin ID : C138165;
UMLS CUI : C5418193;
Semantic type(s)
- concept_is_in_subset
- has_target
