" /> Abemaciclib Mesylate - CISMeF





Preferred Label : Abemaciclib Mesylate;

NCIt synonyms : LY-2835219 Methanesulfonate;

NCIt definition : The mesylate salt of abemaciclib, an orally available cyclin-dependent kinase (CDK) inhibitor that targets the cyclin D1-CDK4 and cyclin D3-CDK6 cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.;

UNII : KKT462Q807;

InChIKey : NCJPFQPEVDHJAZ-UHFFFAOYSA-N;

CAS number : 1231930-82-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1231930-82-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : LY-2835219 methanesulfonate;

NCI Metathesaurus CUI : CL970947;

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12/05/2024


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