Abemaciclib - CISMeF

Preferred Label : Abemaciclib;

NCIt synonyms : 2-Pyrimidinamine, N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl);

NCIt definition : An orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.;

UNII : 60UAB198HK;

InChIKey : UZWDCWONPYILKI-UHFFFAOYSA-N;

CAS number : 1231929-97-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1231929-97-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Verzenio;

Molecule name : LY-2835219;

Codes from synonyms : 4;

Details

Origin ID

C97660;

UMLS CUI

C3852841;

Automatic exact mappings (from CISMeF team)
- Abemaciclib [ICD-11 Extension code]
- abemaciclib [ATC Code]
Currated CISMeF NLP mapping
- Abemaciclib (substance) [SNOMED CT concept]
- abemaciclib [MeSH concept]
- abemaciclib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing abemaciclib (medicinal product) [SNOMED CT concept]
- Verzenio [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Abemaciclib (substance) [SNOMED CT concept]
- Product containing abemaciclib (medicinal product) [SNOMED CT concept]
- abemaciclib [MeSH concept]
- abemaciclib [MeSH Supplementary Concept]
- abemaciclib [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Abemaciclib Mesylate [NCIt concept]
has_target
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
is_component_of_chemotherapy_regimen
- Abemaciclib Regimen [NCIt concept]
- Abemaciclib/Anastrozole Regimen [NCIt concept]
- Abemaciclib/Exemestane Regimen [NCIt concept]
- Abemaciclib/Fulvestrant Regimen [NCIt concept]
- Abemaciclib/Fulvestrant/Leuprolide Regimen [NCIt concept]
- Abemaciclib/Letrozole Regimen [NCIt concept]
- Abemaciclib/Tamoxifen Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Abemaciclib Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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