Preferred Label : CDK4/6 Inhibitor HS-10342;
NCIt definition : An orally bioavailable, small molecular, selective inhibitor of cyclin-dependent kinase
(CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral
administration, CDK4/6 inhibitor HS-10342 selectively inhibits CDK4 and CDK6, which
inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase,
prevents CDK-mediated G1-S-phase transition and leads to cell cycle arrest. This suppresses
DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine
kinases that are upregulated in many tumor cell types and play a key role in the regulation
of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation.;
Molecule name : HS-10342; HS 10342;
NCI Metathesaurus CUI : CL1383163;
Origin ID : C170749;
UMLS CUI : C5417810;
Semantic type(s)
- concept_is_in_subset
- has_target
