Preferred Label : CDK4 Inhibitor P1446A-05;
NCIt synonyms : CDK4 Serine Threonine Kinase Inhibitor P1446A-05;
NCIt definition : A protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with
potential antineoplastic activity. CDK4 inhibitor P1446A-05 specifically inhibits
CDK4-mediated G1-S phase transition, arresting cell cycling and inhibiting cancer
cell growth. The serine/threonine kinase CDK4 is found in a complex with D-type G1
cyclins and is the first kinase to become activated upon mitogenic stimulation, releasing
cells from a quiescent stage into the G1/S growth cycling stage; CDK-cyclin complexes
have been shown to phosphorylate the retinoblastoma (Rb) transcription factor in early
G1, displacing histone deacetylase (HDAC) and blocking transcriptional repression.;
Molecule name : P1446A-05;
NCI Metathesaurus CUI : CL388407;
Origin ID : C80049;
UMLS CUI : C2703208;
Semantic type(s)
- concept_is_in_subset
- has_target
