Preferred Label : Verubulin;
NCIt synonyms : 4-quinazolinamine, N-(4-methoxyphenyl)-N,2-dimethyl-; N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine;
NCIt definition : A quinazoline derivative with potential antineoplastic activities. Verubulin binds
to and inhibits tubulin polymerization and interrupts microtubule formation, resulting
in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and
cell death. This agent is not a substrate for several subtypes of multidrug resistance
ABC transporters, and may be useful for treating multidrug resistant tumors. In addition,
as a vascular disrupting agent, verubulin disrupts tumor microvasculature specifically,
which may result in acute ischemia and massive tumor cell death. In addition, verubulin
is able to cross the blood-brain barrier and accumulate in the brain.;
UNII : X97O9FTB92;
InChIKey : SNHCRNMVYDHVDT-UHFFFAOYSA-N;
CAS number : 827031-83-4;
Molecule name : MX-128495;
Chemical formula : C17H17N3O;
Origin ID : C96747;
UMLS CUI : C2002404;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
