Preferred Label : Verubulin Hydrochloride;
NCIt synonyms : Microtubule Inhibitor MPC-6827; N-(4-methoxyphenyl)-n,2-dimethylquinazolin-4-amine Hydrochloride;
NCIt definition : The hydrochloride salt form of verubulin, a quinazoline derivative with potential
dual antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization
and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly,
cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate
for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein,
multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein
1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors
that express these transporters. In addition, as a vascular disrupting agent (VDA),
verubulin appears to disrupt tumor microvasculature specifically, which may result
in acute ischemia and massive tumor cell death.;
UNII : 33380QZ0QW;
InChIKey : VYUWDIKZJLOZJL-UHFFFAOYSA-N;
CAS number : 917369-31-4;
Drug name : Azixa;
Molecule name : MPC-6827;
Chemical formula : C17H17N3O.HCl;
Origin ID : C64782;
UMLS CUI : C2980072;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
