Preferred Label : Bizelesin;
NCIt synonyms : Benzo(1,2-b:4,3-b')dipyrrol-4-ol, 6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,
(S-(R*,R*)))-;
NCIt related terms : Benzo[1,2-b:4,3-b']dipyrrol-4-ol, 6, 6'-[carbonylbis(imino- 1H-indole-5, 2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,
(S-(R*,R*))];
NCIt definition : A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to
the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting
DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and
triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called alkylating
agents. It is also an antitumor antibiotic.;
UNII : L0O9OBI87E;
InChIKey : FONKWHRXTPJODV-DNQXCXABSA-N;
CAS number : 129655-21-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 129655-21-6
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G-SRS /a ;
Molecule name : U-77779;
Chemical formula : C43H36Cl2N8O5;
NSC code : 615291;
Codes from synonyms : NSC0615291; CDR0000045543;
Origin ID : C1472;
UMLS CUI : C0209891;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
