Oral Ixabepilone

Preferred Label : Oral Ixabepilone;

NCIt definition : An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at the G2-M phase and leads to apoptosis within fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to intravenously administered ixabepilone, the oral formulation provides a more manageable way to administer this agent.;

NCI Metathesaurus CUI : CL415081;

Details

Origin ID

C63478;

UMLS CUI

C4721743;

See also inter- (CISMeF)
- Product containing ixabepilone (medicinal product) [SNOMED CT concept]
- ixabepilone [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ixabepilone (substance) [SNOMED CT concept]
- Product containing ixabepilone (medicinal product) [SNOMED CT concept]
- ixabepilone [ATC Code]
- ixabepilone [MeSH concept]
- ixabepilone [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- Ixabepilone (substance) [SNOMED CT concept]
- ixabepilone [MeSH Supplementary Concept]
- ixabepilone [MeSH concept]
chemical_or_drug_affects_gene_product
- Tubulin [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of G2 to M Transition [NCIt concept]
- Negative Regulation of Mitosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
chemical_or_drug_plays_role_in_biological_process
- Negative Regulation of Microtubule Depolymerization [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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