Preferred Label : Iso-fludelone;
NCIt synonyms : 17-Iso-oxazole-fludelone; 17-Iso-oxazole-26-F3-9,10-dehydro-12,13-desoxy-epothilone B; KOSN-1724;
NCIt definition : A third-generation epothilone B analogue with potential anti-mitotic and antineoplastic
activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and
stabilizes microtubules against depolymerization, which may result in the inhibition
of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations
of epothilones, iso-fludelone exhibits increased stability, water solubility, potency,
duration of action, tumor penetration as well as reduced toxicity. In addition, this
agent is a not a substrate of the P-glycoprotein (P-gp), a multidrug resistance pump
often overexpressed in cancer cells.;
UNII : 6MUO20693U;
CAS number : 693272-98-9;
Molecule name : KOS-1803;
NCI Metathesaurus CUI : CL429824;
Origin ID : C97332;
UMLS CUI : C4722474;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- chemical_or_drug_plays_role_in_biological_process
- concept_is_in_subset
- has_target
