Preferred Label : Ixabepilone;
NCIt synonyms : Azaepothilone B; Epothilone; Epothilone-B BMS 247550; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione;
NCIt related terms : BMS-247550; Ixempra;
NCIt definition : An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic
activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule
stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing
tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant
cell lines.;
Alternative definition : NCI-GLOSS: A drug used to treat metastatic or locally advanced breast cancer that
has not improved after treatment with certain other anticancer drugs. It is also being
studied in the treatment of other types of cancer. Ixempra stops the growth of tumor
cells by blocking cell division. It is a type of epothilone analog.;
UNII : K27005NP0A;
InChIKey : FABUFPQFXZVHFB-PVYNADRNSA-N;
CAS number : 219989-84-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 219989-84-1
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G-SRS /a ;
Drug name : Ixempra;
Molecule name : BMS 247550; BMS-247550;
Chemical formula : C27H42N2O5S;
NSC code : 710428;
ChEBI ID : CHEBI:63605;
Codes from synonyms : 50584; CDR0000574038; CDR0000367463; CDR0000044891; 288;
Origin ID : C37452;
UMLS CUI : C1135132;
- Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- chemical_or_drug_plays_role_in_biological_process
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen