Ixabepilone - CISMeF

Preferred Label : Ixabepilone;

NCIt synonyms : Azaepothilone B; Epothilone; Epothilone-B BMS 247550; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione;

NCIt related terms : BMS-247550; Ixempra;

NCIt definition : An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.;

Alternative definition : NCI-GLOSS: A drug used to treat metastatic or locally advanced breast cancer that has not improved after treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ixempra stops the growth of tumor cells by blocking cell division. It is a type of epothilone analog.;

UNII : K27005NP0A;

InChIKey : FABUFPQFXZVHFB-PVYNADRNSA-N;

CAS number : 219989-84-1;

Drug name : Ixempra;

Molecule name : BMS 247550; BMS-247550;

Chemical formula : C27H42N2O5S;

NSC code : 710428;

ChEBI ID : CHEBI:63605;

Codes from synonyms : 50584; CDR0000574038; CDR0000367463; CDR0000044891; 288;

Details

Origin ID

C37452;

UMLS CUI

C1135132;

Automatic exact mappings (from CISMeF team)
- Epothilone (substance) [SNOMED CT concept]
- Ixabepilone [ICD-11 Extension code]
- epothilone A [MeSH Supplementary Concept]
- epothilone A [MeSH concept]
See also inter- (CISMeF)
- Product containing ixabepilone (medicinal product) [SNOMED CT concept]
- epothilones [MeSH Descriptor]
- epothilones [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ixabepilone (substance) [SNOMED CT concept]
- Product containing ixabepilone (medicinal product) [SNOMED CT concept]
- ixabepilone [ATC Code]
- ixabepilone [MeSH concept]
- ixabepilone [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- ixabepilone [ATC Code]
chemical_or_drug_affects_gene_product
- Tubulin [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of G2 to M Transition [NCIt concept]
- Negative Regulation of Mitosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
chemical_or_drug_plays_role_in_biological_process
- Negative Regulation of Microtubule Depolymerization [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin [NCIt concept]
is_component_of_chemotherapy_regimen
- BMS-247550/Carboplatin [NCIt concept]
- BMS-247550/Estramustine [NCIt concept]
- Bevacizumab/Ixabepilone Regimen [NCIt concept]
- Capecitabine/Ixabepilone Regimen [NCIt concept]
- Carboplatin/Ixabepilone [NCIt concept]
- Carboplatin/Ixabepilone/Trastuzumab [NCIt concept]
- Cisplatin/Ixabepilone [NCIt concept]
- Estramustine/Ixabepilone [NCIt concept]
- Gemcitabine/Ixabepilone [NCIt concept]
- Ixabepilone Regimen [NCIt concept]
- Ixabepilone/Trastuzumab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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