Positive Transcription Elongation Factor B

Preferred Label : Positive Transcription Elongation Factor B;

NCIt synonyms : P-TEFb;

NCIt definition : A cyclin-dependent kinase complex that promotes the release of RNA polymerase II (Pol II) from promoter proximal pausing and leads to transcript elongation and mRNA synthesis. This complex is a heterodimer comprised of the serine-threonine kinase cyclin-dependent kinase 9 and either cyclin-T1, cyclin-T2 or cyclin-K.;

NCI Metathesaurus CUI : CL1647678;

Details

Origin ID

C178137;

UMLS CUI

C0663446;

Automatic exact mappings (from CISMeF team)
- positive transcriptional elongation factor B [MeSH concept]
- positive transcriptional elongation factor b [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- positive transcriptional elongation factor B [MeSH concept]
- positive transcriptional elongation factor b [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Cyclin-Dependent Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- Serine/Threonine Phosphorylation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
has_gene_product_element
- Cyclin-Dependent Kinase 9 [NCIt concept]
- Cyclin-K [NCIt concept]
is_target
- Atuveciclib [NCIt concept]

Keyword's position in hierarchy(ies) :

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