Preferred Label : Atuveciclib;
NCIt synonyms : 1,3,5-Triazin-2-amine, 4-(4-Fluoro-2-methoxyphenyl)-N-(3-((S-methylsulfonimidoyl)methyl)phenyl)-,
( )-;
NCIt definition : An inhibitor of positive transcription elongation factor b (P-TEFb), which is composed
of cyclin-dependent kinase 9 (CDK9) and cyclin-T (CycT), with potential antineoplastic
activity. Upon administration, atuveciclib binds to and inhibits the activity of P-TEFb,
thereby preventing the phosphorylation of its downstream target, the carboxyl terminal
domain (CTD) of RNA polymerase II (RNA Pol II), and inhibiting the activation of transcriptional
elongation by RNA Pol II. This prevents the transcription of tumor promoting genes,
induces tumor cell apoptosis, and inhibits tumor cell proliferation. P-TEFb plays
an important role in the regulation of gene transcription; over-activation in cancer
cells leads to both the transcription of key tumor-promoting genes and cancer cell
proliferation.;
UNII : 63Q7F59W0V;
InChIKey : ACWKGTGIJRCOOM-HHHXNRCGSA-N;
CAS number : 1414943-94-4;
Molecule name : BAY 1143572; BAY1143572;
NCI Metathesaurus CUI : CL471744;
Origin ID : C121456;
UMLS CUI : C4548853;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
