CDK8/19 Inhibitor RVU120

Preferred Label : CDK8/19 Inhibitor RVU120;

NCIt synonyms : CDK8/19 Inhibitor SEL 120;

NCIt related terms : SEL-120;

NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor RVU120 targets, binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell cycle, are overexpressed in certain cancer cell types and play key roles in tumor cell proliferation.;

UNII : SDM3M518PJ;

CAS number : 1609452-30-3;

Molecule name : SEL 120; SEL 120-34A; SEL-120; SEL 120-34; RVU-120; RVU 120;

NCI Metathesaurus CUI : CL978865;

Détails

Origin ID

C165747;

UMLS CUI

C5237424;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Cyclin-Dependent Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cyclin-Dependent Kinase [NCIt concept]

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