NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with
potential antineoplastic and chemoprotective activities. Upon oral administration,
CDK8/19 inhibitor RVU120 targets, binds to and inhibits the activity of CDK8/19, which
prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective
transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing
tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell
cycle, are overexpressed in certain cancer cell types and play key roles in tumor
cell proliferation.;
UNII : SDM3M518PJ;
CAS number : 1429515-59-2;
Molecule name : SEL 120; SEL 120-34A; SEL-120; SEL 120-34; RVU-120; RVU 120;