" /> CDK8/19 Inhibitor SEL 120 - CISMeF





Preferred Label : CDK8/19 Inhibitor SEL 120;

NCIt related terms : SEL-120;

NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor SEL 120 targets, binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell cycle, are overexpressed in certain cancer cell types and play key roles in tumor cell proliferation.;

UNII : SDM3M518PJ;

CAS number : 1429515-59-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1429515-59-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SEL 120; SEL 120-34A; SEL-120; SEL 120-34;

NCI Metathesaurus CUI : CL978865;

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14/05/2024


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