" /> CDK8/19 Inhibitor RVU120 - CISMeF





Preferred Label : CDK8/19 Inhibitor RVU120;

NCIt synonyms : CDK8/19 Inhibitor SEL 120;

NCIt related terms : SEL-120;

NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor RVU120 targets, binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell cycle, are overexpressed in certain cancer cell types and play key roles in tumor cell proliferation.;

UNII : SDM3M518PJ;

CAS number : 1609452-30-3;

Molecule name : SEL 120; SEL 120-34A; SEL-120; SEL 120-34; RVU-120; RVU 120;

NCI Metathesaurus CUI : CL978865;

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30/07/2025


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