CDK Inhibitor AT7519

Preferred Label : CDK Inhibitor AT7519;

NCIt synonyms : Cyclin-Dependent Kinase Inhibitor AT7519M;

NCIt related terms : CDKI AT7519; AT7519M; CDK inhibitor AT7519M; AT-7519;

NCIt definition : An orally bioavailable small molecule with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some types of cancer cells.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. AT7519M blocks enzymes needed for cells to divide. It is a type of cyclin-dependent kinase inhibitor.;

UNII : X1BF92PW9T;

CAS number : 844442-38-2;

Molecule name : AT7519; AT7519M;

Chemical formula : C16H17Cl2N5O2;

Codes from synonyms : CDR0000530319; CDR0000546733;

Details

Origin ID

C64761;

UMLS CUI

C1879520;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AT 7519 [MeSH concept]
Validated automatic mappings to NTBT
- 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Cyclin-Dependent Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cyclin-Dependent Kinase [NCIt concept]

Keyword's position in hierarchy(ies) :

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