" /> CDK9 Inhibitor AZD4573 - CISMeF





Preferred Label : CDK9 Inhibitor AZD4573;

NCIt related terms : AZD-4573;

NCIt definition : A selective, short-acting inhibitor of the serine/threonine cyclin-dependent kinase 9 (CDK9), the catalytic subunit of the RNA polymerase II (RNA Pol II) elongation factor positive transcription elongation factor b (PTEF-b; PTEFb), with potential antineoplastic activity. Upon intravenous administration, AZD4573 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II, leading to the inhibition of gene transcription of various anti-apoptotic proteins. This induces cell cycle arrest and apoptosis, and leads to a reduction in tumor cell proliferation. CDK9 regulates elongation of transcription through phosphorylation of RNA polymerase II at serine 2 (p-Ser2-RNAPII). It is upregulated in various tumor cell types and plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.;

UNII : E5XSP3X68B;

CAS number : 2057509-72-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2057509-72-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AZD 4573; AZD-4573;

NCI Metathesaurus CUI : CL554533;

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Keyword's position in hierarchy(ies) : arborescence

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14/05/2024


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