Nucleotide Excision Repair Pathway

Preferred Label : Nucleotide Excision Repair Pathway;

NCIt related terms : Nucleotide excision repair;

Alternative definition : KEGG: Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.;

KEGG ID : hsa03420;

Details

Origin ID

C91447;

UMLS CUI

C2984260;

Automatic exact mappings (from CISMeF team)
- dna repair [MeSH Descriptor]
- nucleotide-excision repair [GO term]
See also inter- (CISMeF)
- nucleotide excision repair [MeSH concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Cullin-4A [NCIt concept]
- Cullin-4B [NCIt concept]
- Cyclin-Dependent Kinase 7 [NCIt concept]
- DNA Damage-Binding Protein 1 [NCIt concept]
- DNA Damage-Binding Protein 2 [NCIt concept]
- DNA Excision Repair Protein ERCC-1 [NCIt concept]
- DNA Excision Repair Protein ERCC-6 [NCIt concept]
- DNA Excision Repair Protein ERCC-8 [NCIt concept]
- DNA Polymerase Delta Catalytic Subunit [NCIt concept]
- DNA Polymerase Delta Subunit 3 [NCIt concept]
- DNA Polymerase Epsilon Catalytic Subunit A [NCIt concept]
- DNA Polymerase Epsilon Subunit 2 [NCIt concept]
- DNA Repair Endonuclease XPF [NCIt concept]
- DNA Repair Protein Complementing XP-A Cells [NCIt concept]
- DNA Repair Protein Complementing XP-C Cells [NCIt concept]
- DNA Repair Protein Complementing XP-G Cells [NCIt concept]
- General Transcription and DNA Repair Factor IIH Helicase Subunit XPD [NCIt concept]
- Replication Factor C Subunit 1 [NCIt concept]
- Replication Factor C Subunit 2 [NCIt concept]
- Replication Factor C Subunit 3 [NCIt concept]
- Replication Factor C Subunit 4 [NCIt concept]
- Replication Factor C Subunit 5 [NCIt concept]
- Replication Protein A 14 kDa [NCIt concept]
- Replication Protein A 32 kDa Subunit [NCIt concept]
- Replication Protein A 70 kDa DNA-Binding Subunit [NCIt concept]
- TFIIH Basal Transcription Factor Complex Helicase XPB Subunit [NCIt concept]
- UV Excision Repair Protein RAD23 Homolog A [NCIt concept]
- UV Excision Repair Protein RAD23 Homolog B [NCIt concept]
pathway_has_gene_element
- CDK7 wt Allele [NCIt concept]
- CUL4A wt Allele [NCIt concept]
- CUL4B wt Allele [NCIt concept]
- DDB1 wt Allele [NCIt concept]
- DDB2 wt Allele [NCIt concept]
- ERCC1 wt Allele [NCIt concept]
- ERCC2 wt Allele [NCIt concept]
- ERCC3 wt Allele [NCIt concept]
- ERCC4 wt Allele [NCIt concept]
- ERCC5 wt Allele [NCIt concept]
- ERCC6 wt Allele [NCIt concept]
- POLD1 wt Allele [NCIt concept]
- POLD3 wt Allele [NCIt concept]
- POLE wt Allele [NCIt concept]
- POLE2 wt Allele [NCIt concept]
- RAD23A wt Allele [NCIt concept]
- RAD23B wt Allele [NCIt concept]
- RFC1 wt Allele [NCIt concept]
- RFC2 wt Allele [NCIt concept]
- RFC3 wt Allele [NCIt concept]
- RFC4 wt Allele [NCIt concept]
- RFC5 wt Allele [NCIt concept]
- RPA1 wt Allele [NCIt concept]
- RPA2 wt Allele [NCIt concept]
- RPA3 wt Allele [NCIt concept]
- XPA wt Allele [NCIt concept]
- XPC wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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