DNA Excision Repair Protein ERCC-1

Preferred Label : DNA Excision Repair Protein ERCC-1;

NCIt synonyms : ERCC1; Excision Repair Cross-Complementing 1; Excision Repair Cross-Complementing-1 Protein;

NCIt definition : DNA excision repair protein ERCC-1 (297 aa, 33 kDa) is encoded by the human ERCC1 gene. This protein plays a role in 5-prime incision during both UV cross-link repair and nucleotide excision repair.;

NCIt note : The C-terminus of DNA excision repair protein ERCC-1 is essential for enzymatic activity and the central region is involved in protein-protein interactions.;

Details

Origin ID

C21437;

UMLS CUI

C1333483;

OMIM relation
- Ercc excision repair 1, endonuclease noncatalytic subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ERCC1 [LOINC component]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- ERCC1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Repair Endonuclease [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Nucleotide Excision Repair Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Embryogenesis [NCIt concept]
- Morphogenesis [NCIt concept]
- Nucleotide Excision Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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