Nucleotide Excision Repair

Preferred Label : Nucleotide Excision Repair;

NCIt synonyms : Transcription-Coupled Repair; Transcription-Coupled Nucleotide Excision Repair; Nucleotide-Excision Repair; NER;

NCIt definition : Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away. Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.;

Details

Origin ID

C20213;

UMLS CUI

C0524550;

Currated CISMeF NLP mapping
- nucleotide excision repair [MeSH concept]
- nucleotide-excision repair [GO term]
- transcription-coupled nucleotide-excision repair [GO term]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- nucleotide excision repair [MeSH concept]
- nucleotide-excision repair [GO term]
- obsolete pyrimidine-dimer repair, DNA damage excision [GO term]
biological_process_involves_gene_product
- DNA Cross-Link Repair 1A Protein [NCIt concept]
- DNA Damage-Binding Protein 1 [NCIt concept]
- DNA Damage-Binding Protein 2 [NCIt concept]
- DNA Excision Repair Protein ERCC-1 [NCIt concept]
- DNA Excision Repair Protein ERCC-6 [NCIt concept]
- DNA Excision Repair Protein ERCC-8 [NCIt concept]
- DNA Ligase 1 [NCIt concept]
- DNA Polymerase Kappa [NCIt concept]
- DNA Repair Endonuclease XPF [NCIt concept]
- DNA Repair Protein Complementing XP-C Cells [NCIt concept]
- DNA Repair Protein Complementing XP-G Cells [NCIt concept]
- Excision Repair Cross-Complementing Family [NCIt concept]
- General Transcription and DNA Repair Factor IIH Helicase Subunit XPD [NCIt concept]
- INO80 Complex [NCIt concept]
- Replication Factor C Subunit 1 [NCIt concept]
- Replication Factor C Subunit 2 [NCIt concept]
- Replication Factor C Subunit 3 [NCIt concept]
- Replication Factor C Subunit 4 [NCIt concept]
- Replication Factor C Subunit 5 [NCIt concept]
- TFIIH Basal Transcription Factor Complex Helicase XPB Subunit [NCIt concept]
- Transcription Elongation Factor A Protein 1 [NCIt concept]
- UV Excision Repair Protein RAD23 Homolog A [NCIt concept]
- UV Excision Repair Protein RAD23 Homolog B [NCIt concept]
- UV-Stimulated Scaffold Protein A [NCIt concept]
biological_process_is_part_of_process
- Cell Survival [NCIt concept]
process_involves_gene
- DCLRE1A Gene [NCIt concept]
- DCLRE1A wt Allele [NCIt concept]
- DDB1 Gene [NCIt concept]
- DDB1 wt Allele [NCIt concept]
- DDB2 Gene [NCIt concept]
- DDB2 wt Allele [NCIt concept]
- ERCC Family Gene [NCIt concept]
- ERCC1 Gene [NCIt concept]
- ERCC1 wt Allele [NCIt concept]
- ERCC2 Gene [NCIt concept]
- ERCC2 wt Allele [NCIt concept]
- ERCC3 Gene [NCIt concept]
- ERCC3 wt Allele [NCIt concept]
- ERCC4 Gene [NCIt concept]
- ERCC4 wt Allele [NCIt concept]
- ERCC5 Gene [NCIt concept]
- ERCC5 wt Allele [NCIt concept]
- ERCC6 Gene [NCIt concept]
- ERCC6 wt Allele [NCIt concept]
- ERCC8 Gene [NCIt concept]
- ERCC8 wt Allele [NCIt concept]
- LIG1 Gene [NCIt concept]
- LIG1 wt Allele [NCIt concept]
- POLK Gene [NCIt concept]
- POLK wt Allele [NCIt concept]
- RAD23A Gene [NCIt concept]
- RAD23A wt Allele [NCIt concept]
- RAD23B Gene [NCIt concept]
- RAD23B wt Allele [NCIt concept]
- RFC1 Gene [NCIt concept]
- RFC1 wt Allele [NCIt concept]
- RFC2 Gene [NCIt concept]
- RFC2 wt Allele [NCIt concept]
- RFC3 Gene [NCIt concept]
- RFC3 wt Allele [NCIt concept]
- RFC4 Gene [NCIt concept]
- RFC4 wt Allele [NCIt concept]
- RFC5 Gene [NCIt concept]
- RFC5 wt Allele [NCIt concept]
- TCEA1 Gene [NCIt concept]
- TCEA1 wt Allele [NCIt concept]
- UVSSA Gene [NCIt concept]
- UVSSA wt Allele [NCIt concept]
- XPC Gene [NCIt concept]
- XPC wt Allele [NCIt concept]

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