Preferred Label : Hec1/Nek2 Inhibitor T-1101 Tosylate;
NCIt synonyms : T1101 Tosylate; T 1101 Tosylate;
NCIt definition : The tosylate salt form of T-1101, an orally bioavailable inhibitor of highly expressed
in cancer 1 (Hec1) and NIMA-related kinase 2 (Nek2), with potential antineoplastic
activity. Upon oral administration, T-1101 specifically targets, binds to and inhibits
the interaction of Hec1 with Nek2. This prevents Hec1/Nek2-mediated signal transduction
pathways, inhibits mitosis, induces apoptosis and tumor cell proliferation. Hec1,
overexpressed in some cancers, is located at the centromere during cell mitosis and
plays an essential role in the pathway of spindle checkpoint. It is correlated with
cancer formation, progression, and survival. Phosphorylation of Hec1 by Nek2 kinase
is essential for its mitotic function.;
Molecule name : TAI-95;
NCI Metathesaurus CUI : CL553272;
Origin ID : C151933;
UMLS CUI : C4726560;
Semantic type(s)
- concept_is_in_subset
- has_target
