Syntaxin-1B Isoform 2

Preferred Label : Syntaxin-1B Isoform 2;

NCIt synonyms : STX1B-DeltaTMD; Syntaxin-1B2; Syntaxin-1B-Delta Transmembrane Domain; STX1B; Syntaxin 1B2; STX1B2;

NCIt definition : Syntaxin-1B isoform 2 (277 aa, 32 kDa) is encoded by the human STX1B gene. This protein is localized in the nuclear matrix and may interact with lamin-A/C and nuclear mitotic apparatus protein 1.;

NCIt note : Due to alternative splicing, syntaxin-1B isoform 2 is missing the canonical syntaxin hydrophobic C-terminal transmembrane domain. This domain has been replaced by a glycine-rich sequence that acts as an unconventional nuclear localization signal. (UniProt);

Details

Origin ID

C208069;

OMIM relation
- Syntaxin 1b [OMIM gene]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- STX1B Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Right Cerebral Hemisphere [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- SNARE Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
gene_product_is_element_in_pathway
- SNARE Proteins Vesicular Transport Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Intracellular Transport [NCIt concept]
- Ligand Binding [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Transport Process [NCIt concept]

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