Nesprin-1 - CISMeF

Preferred Label : Nesprin-1;

NCIt synonyms : Spectrin Repeat Containing Nuclear Envelope Protein 1; Nesprin 1; SYNE1; Myocyte Nuclear Envelope Protein 1; KASH Domain-Containing Protein 1; Nuclear Envelope Spectrin Repeat Protein 1; Spectrin Repeat-Containing Nuclear Envelope Protein 1; Syne-1; Enaptin; KASH1; Synaptic Nuclear Envelope Protein 1; Myne-1;

NCIt definition : Nesprin-1 (8797 aa, 1011 kDa) is encoded by the human SYNE1 gene. This protein plays a role in linking the nuclear lamina and the cytoskeleton.;

NCIt note : Nesprin-1 is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex that connects nuclear lamina proteins to the actin cytoskeleton. These links transmit mechanical forces across the nuclear envelope and regulate nuclear movement and positioning. (UniProt);

NCI Metathesaurus CUI : CL552093;

Details

Origin ID

C150329;

UMLS CUI

C4724748;

Automatic exact mappings (from CISMeF team)
- Spectrin repeat-containing nuclear envelope protein 1 [OMIM gene]
- spectrin repeat containing nuclear envelope protein 1 [ORDO Gene]
- spectrin repeat containing nuclear envelope protein 1 [HGNC gene]
OMIM relation
- Spectrin repeat-containing nuclear envelope protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- SYNE1 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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