Mixed Lineage Kinase Domain-Like Protein

Preferred Label : Mixed Lineage Kinase Domain-Like Protein;

NCIt synonyms : Mixed Lineage Kinase Domain Like; Mixed Lineage Kinase Domain-Like; MLKL; hMLKL;

NCIt definition : Mixed lineage kinase domain-like protein (471 aa, 54 kDa) is encoded by the human MLKL gene. This protein is involved in tumor necrosis factor-dependent necroptosis.;

NCIt note : Mixed lineage kinase domain-like protein contains an inactive protein kinase domain.;

NCI Metathesaurus CUI : CL523860;

Details

Origin ID

C134711;

UMLS CUI

C4521461;

Automatic exact mappings (from CISMeF team)
- Mixed lineage kinase domain-like protein [OMIM gene]
OMIM relation
- Mixed lineage kinase domain-like protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MLKL Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Coiled-Coil Domain [NCIt concept]
- Cytoplasm [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Intracellular Signaling Process [NCIt concept]
- Positive Regulation of Cell Death [NCIt concept]
- Positive Regulation of Necrotic Process [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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