Transforming Acidic Coiled-Coil-Containing Protein 1

Preferred Label : Transforming Acidic Coiled-Coil-Containing Protein 1;

NCIt synonyms : Acidic Coiled-Coil Protein 1; Gastric Cancer Antigen Ga55; Taxin 1; TACC1 Protein; TACC1; Transforming Acidic Coiled-Coil Containing Protein-1;

NCIt definition : Transforming acidic coiled-coil-containing protein 1 (805 aa, 88 kDa) is encoded by the human TACC1 gene. This protein may be involved in cell division and histogenesis.;

NCIt note : Transforming acidic coiled-coil-containing protein 1 is rich in serine, proline, and acidic residues, with a 20-amino acid N-terminus rich in tryptophan, and contains two nuclear localization signals but no DNA- or RNA-binding domains. A 200-residue C-terminus with extensive alpha-helical segments is expected to adopt a coiled-coil structure. This nuclear protein is concentrated at centrosomes and interacts with microtubules and tubulin. (Swiss-Prot, OMIMI);

Details

Origin ID

C21225;

UMLS CUI

C0907959;

OMIM relation
- Transforming, acidic, coiled-coil-containing protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TACC1 protein, human [MeSH concept]
- TACC1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- TACC1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
gene_product_malfunction_associated_with_disease
- Breast Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Ligand Binding [NCIt concept]

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