" /> SARS-CoV-2 Spike Glycoprotein - CISMeF





Preferred Label : SARS-CoV-2 Spike Glycoprotein;

NCIt synonyms : S Glycoprotein; S Protein; SARS-CoV-2 Spike Protein; Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein; Spike Glycoprotein; Peplomer Protein; SARS-CoV-2 S Protein; SARS2 Spike Protein; SARS2 S Protein; SARS2 Spike Glycoprotein;

NCIt related terms : Full Length Spike Trimer;

NCIt definition : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (1273 aa, 141 kDa) is encoded by the SARS-CoV-2 S gene. This protein plays a role in binding to host cell membranes and the initiation of viral infection.;

Alternative definition : CDISC: The approximately 180-200 kDa transmembrane, receptor binding protein from the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2).;

NCIt note : SARS-CoV-2 spike glycoprotein is sequentially cleaved to form spike protein S1 (amino acid residues 13-685), spike protein S2 (residues 686-1273) and spike protein S2' (residues 816-1273). S1 binds to angiotensin-converting enzyme 2, while S2 and S2' mediate fusion of the virion and cellular membranes. (UniProt);

NCI Metathesaurus CUI : CL1647912;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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