NCIt synonyms : Anti-SARS-CoV-2 Spike Protein Monoclonal Antibody STI-2020; Affinity Matured COVI-GUARD; Anti-SARS-CoV-2 S Protein Monoclonal Antibody STI-2020;
NCIt definition : A neutralizing human monoclonal antibody directed against the spike (S) protein of
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially
be used for immunization against Coronavirus disease 2019 (COVID-19). Upon administration,
plutavimab specifically targets and binds to the S1 subunit of the SARS-CoV-2 S protein,
thereby blocking viral attachment and entry into human cells and may thereby neutralize
SARS-CoV-2. This may slow the progression of the disease and accelerate recovery,
and may potentially provide temporary protection against infection with SARS-CoV-2.
S protein, usually found on the surface of SARS-CoV-2, plays an essential role in
the infection pathway of the SARS-CoV-2 virus. The potency of STI-2020 was enhanced
by an affinity maturation process.;
UNII : 12U14K0SR5;
CAS number : 2529854-88-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2529854-88-2
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