NCIt definition : A neutralizing human immunoglobulin G1 (IgG1) monoclonal antibody directed against
the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
and other SARS-like CoVs, that can potentially be used for immunization against COVID-19.
Upon administration, adintrevimab specifically targets and binds to a highly conserved
epitope in the receptor-binding domain (RBD) of SARS-CoV-2 S protein, thereby blocking
viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2.
This may slow the progression of the disease and accelerate recovery, and may potentially
provide temporary protection against infection with SARS-CoV-2. S protein, usually
found on the surface of SARS-CoV-2, plays an essential role in the infection pathway
of the SARS-CoV-2 virus.;
Semantic type(s)