Preferred Label : Angiopoietin-1;
NCIt synonyms : Angiopoietin 1; ANG-1; ANGPT1; ANG1;
NCIt definition : Angiopoietin-1 (498 aa, 58 kDa) is encoded by the human ANGPT1 gene. This protein
is involved in both signal transduction and angiogenesis.;
NCIt note : Encoded by human ANGPT1 Gene, Angiopoietin-1 is a 498-amino acid 57.5 kD (precursor)
secreted glycoprotein ligand for the endothelial TIE2 receptor tyrosine kinase and
contains a predicted coiled-coil domain and a fibrinogen-like C-terminus. Its expression
in endothelial and early hematopoietic cells suggests an action in vascular development.
Antagonized by Angiopoietin-2, ANGPT1 structure differs from other angiogenic factors
or ligands for receptor tyrosine kinases and its actions are distinct from VEGF, necessary
for early stages of vascular development. ANGPT1 acts in vascular remodeling, maturation,
and stability. ANGPT1 and TIE1 are critical for right side, but not left side, venous
system development. (OMIM, Swiss-Prot, and NCI);
Origin ID : C18042;
UMLS CUI : C0533668;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_plays_role_in_biological_process
- is_target
