NCIt definition : An immunoglobulin (Ig) G2 monoclonal antibody targeting the proangiogenic cytokines
angiopoietin 1 (Ang1) and 2 (Ang2), with potential anti-angiogenic and antineoplastic
activities. Upon administration, anti-angiopoietin monoclonal antibody AMG 780 binds
to Ang1 and Ang2. This prevents the binding of the angiopoietin ligands to their receptor
Tie2 (TEK), an endothelial cell-specific receptor tyrosine kinase. This prevents Tie2-mediated
signaling and results in an inhibition of Tie2-expressing, tumor-stimulated endothelial
cell proliferation, which prevents angiogenesis and inhibits tumor cell proliferation.;
Semantic type(s)