MYC Box-Dependent-Interacting Protein 1

Preferred Label : MYC Box-Dependent-Interacting Protein 1;

NCIt synonyms : MYC Box Dependent Interacting Protein 1; Box-Dependent MYC-Interacting Protein-1; BIN1; Amphiphysin-Like Protein; Amphiphysin-Like Box Dependant MYC Interacting Protein 1; Amphiphysin II; Box-Dependent Myc-Interacting Protein 1; Bridging Integrator-1 Protein; Bridging Integrator 1;

NCIt definition : Myc box-dependent-interacting protein 1 (593 aa, 65 kDa) is encoded by the human BIN1 gene. This protein is involved in caspase-independent apoptosis and may be involved in synaptic vesicle endocytosis.;

NCIt note : There are at least 11 isoforms of Myc box-dependent-interacting protein 1 that are the result of alternative splicing. Some isoforms are ubiquitous, while others are expressed in muscle or in the central nervous system. (UniProt and EntrezGene).;

Details

Origin ID

C28720;

UMLS CUI

C4316932;

Currated CISMeF NLP mapping
- amphiphysin II [MeSH concept]
OMIM relation
- Bridging integrator 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- BIN1 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Endocytosis Pathway [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Endocytotic Process [NCIt concept]
- Intracellular Signaling Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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