FACT Complex Subunit SPT16

Preferred Label : FACT Complex Subunit SPT16;

NCIt synonyms : hSPT16; Facilitates Chromatin Transcription Complex Subunit SPT16; SUPT16H; Chromatin-Specific Transcription Elongation Factor 140 kDa Subunit; FACT 140 kDa Subunit; FACTp140; Facilitates Chromatin Remodeling 140 kDa Subunit;

NCIt definition : FACT complex subunit SPT16 (1047 aa, 120 kDa) is encoded by the human SUPT16H gene. This protein plays a role in chromosome remodeling that regulates mRNA elongation, DNA replication and DNA repair.;

NCIt note : Although FACT complex subunit SPT16 is related to the peptidase M24 family, this protein lacks the conserved metallopeptidase active site residues. (UniProt);

Details

Origin ID

C181643;

UMLS CUI

C1454861;

Automatic exact mappings (from CISMeF team)
- SPT16 homolog, facilitates chromatin remodeling subunit [HGNC gene]
- Spt16 homolog, facilitates chromatin remodeling subunit [OMIM gene]
OMIM relation
- Spt16 homolog, facilitates chromatin remodeling subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SUPT16H protein, human [MeSH Supplementary Concept]
- SUPT16H protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SUPT16H Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Chromatin [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
gene_product_is_physical_part_of
- FACT Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Transcription Elongation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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