E3 Ubiquitin-Protein Ligase RFWD3

Preferred Label : E3 Ubiquitin-Protein Ligase RFWD3;

NCIt synonyms : RING Finger Protein 201; EC 2.3.2.27; RING-Type E3 Ubiquitin Transferase RFWD3; RING Finger and WD Repeat Domains-Containing Protein 3; RING Finger and WD Repeat Domain-Containing Protein 3; RFWD3;

NCIt definition : E3 ubiquitin-protein ligase RFWD3 (774 aa, 85 kDa) is encoded by the human RFWD3 gene. This protein is involved in the ubiquitination of proteins that regulate the DNA damage checkpoint during the cell cycle.;

NCIt note : Substrates for E3 ubiquitin-protein ligase RFWD3 include cellular tumor antigen p53. (UniProt);

Details

Origin ID

C138093;

UMLS CUI

C2933578;

Automatic exact mappings (from CISMeF team)
- Ring finger and wd repeat domains-containing protein 3 [OMIM gene]
- ring finger and WD repeat domain 3 [ORDO Gene]
OMIM relation
- Ring finger and wd repeat domains-containing protein 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- RFWD3 protein, human [MeSH Supplementary Concept]
- RFWD3 protein, human [MeSH concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- RFWD3 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Fanconi Anemia Complementation Group Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- WD Repeat [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- G1/S Transition Checkpoint [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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