WD Repeat - CISMeF

Preferred Label : WD Repeat;

NCIt synonyms : Trp-Asp Repeat; Tryptophan-Aspartate Repeat; WD Domain; WD40 Domain; G-Beta Repeat;

NCIt definition : WD40 Repeats are found in signal transduction, mRNA processing, cytoskeletal assembly, and cell cycle proteins; none are catalytic. G-beta is the prototypic WD40 protein. WD-40 proteins contain 5-8 repeats of about 40 residues, with a central Trp-Asp (WD) motif. The repeats may span the entire protein or make up either terminal or the central section. WD40 domains serve as a platform to which proteins stably or reversibly bind; some may recognize phosphoSer and -Thr peptides. The repeat forms a closed ring propeller with seven blades each composed of a four-stranded anti-parallel b-sheet. Each repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal repeat completes the blade of the first repeat. Residues on the propeller top surface likely coordinate interactions with other proteins or ligands.;

Details

Origin ID

C14111;

UMLS CUI

C1520109;

Automatic exact mappings (from CISMeF team)
- WD40 Repeats [MeSH Descriptor]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- WD40 Repeats [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- Aladin [NCIt concept]
- Angio-Associated Migratory Cell Protein [NCIt concept]
- Autophagy-Related Protein 16-1 [NCIt concept]
- Cilia- and Flagella-Associated Protein 251 [NCIt concept]
- Ciliogenesis and Planar Polarity Effector 1 [NCIt concept]
- Coronin-1A [NCIt concept]
- DDB1- and CUL4-Associated Factor 12-Like Protein 2 [NCIt concept]
- DDB1- and CUL4-Associated Factor 5 [NCIt concept]
- DDB1- and CUL4-Associated Factor 7 [NCIt concept]
- DENN Domain-Containing Protein 3 [NCIt concept]
- DNA Excision Repair Protein ERCC-8 [NCIt concept]
- Denticleless Protein Homolog [NCIt concept]
- Dynein Axonemal Intermediate Chain 1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase COP1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RFWD3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRAF7 [NCIt concept]
- F-Box-Like/WD Repeat-Containing Protein TBL1X [NCIt concept]
- F-Box-Like/WD Repeat-Containing Protein TBL1XR1 [NCIt concept]
- F-Box-Like/WD Repeat-Containing Protein TBL1Y [NCIt concept]
- F-Box/WD Repeat-Containing Protein 1A [NCIt concept]
- F-Box/WD Repeat-Containing Protein 7 [NCIt concept]
- Fizzy-Related Protein Homolog [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3 [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Beta-5 [NCIt concept]
- Histone-Binding Protein RBBP4 [NCIt concept]
- Histone-Binding Protein RBBP7 [NCIt concept]
- Jouberin [NCIt concept]
- Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2 [NCIt concept]
- Leucine-Rich Repeat and WD Repeat-Containing Protein 1 [NCIt concept]
- Lipopolysaccharide-Responsive and Beige-Like Anchor Protein [NCIt concept]
- Lysosomal-Trafficking Regulator [NCIt concept]
- Mitogen-Activated Protein Kinase-Binding Protein 1 [NCIt concept]
- Neurobeachin [NCIt concept]
- Partner and Localizer of BRCA2 [NCIt concept]
- Polycomb Protein EED [NCIt concept]
- Protein FAN [NCIt concept]
- Protein Transport Protein Sec31A [NCIt concept]
- Splicing Factor 3B Subunit 3 [NCIt concept]
- Target of Rapamycin Complex Subunit LST8 [NCIt concept]
- Telomerase Cajal Body Protein 1 [NCIt concept]
- Telomerase Protein Component 1 [NCIt concept]
- Titin [NCIt concept]
- Transducin Beta-Like Protein 2 [NCIt concept]
- Transducin-Like Enhancer Protein 1 [NCIt concept]
- Transducin-Like Enhancer Protein 2 [NCIt concept]
- Transducin-Like Enhancer Protein 3 [NCIt concept]
- Transducin-Like Enhancer Protein 4 [NCIt concept]
- WD Repeat and Coiled-Coil-Containing Protein [NCIt concept]
- WD Repeat and FYVE Domain-Containing Protein 2 [NCIt concept]
- WD Repeat-Containing Protein 26 [NCIt concept]
- WD Repeat-Containing Protein 5 [NCIt concept]
- mRNA Export Factor RAE1 [NCIt concept]

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