F-Box/WD Repeat-Containing Protein 7

Preferred Label : F-Box/WD Repeat-Containing Protein 7;

NCIt synonyms : F-box and WD-40 domain protein 7; AGO Protein; F-Box Protein SEL-10; F-box protein FBW7; FBXW7; Archipelago Homolog Protein; Archipelago Homolog; FBXW7 Protein; Homolog of C elegans Sel-10; hCdc4; SEL-10; hAgo; F-Box Protein FBX30; F-Box and WD40 Domain Protein 7;

NCIt definition : F-box/WD repeat-containing protein 7 (707 aa, 80 kDa) is encoded by the human FBXW7 gene. This protein plays a role in the regulation of protein ubiquitination.;

NCIt note : F-box/WD repeat-containing protein 7 is a subunit of the SKP1-CUL1-F-box protein (SCF) E3 ubiquitin-protein ligase complex, which regulates the ubiquitination and subsequent proteasomal degradation of cyclin-E, MYC, NOTCH1 intracellular domain (NICD), and probably PSEN1. (UniProt);

Details

Origin ID

C21512;

UMLS CUI

C0755295;

Automatic exact mappings (from CISMeF team)
- F-Box-WD Repeat-Containing Protein 7 [MeSH Descriptor]
- F-box and wd40 domain protein 7 [OMIM gene]
OMIM relation
- F-box and wd40 domain protein 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FBXW7 protein, human [MeSH Supplementary Concept]
- FBXW7 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FBXW7 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Ligand Binding Protein [NCIt concept]
gene_product_has_gene_product_variant
- FBXW7 NP_361014.1:p.R465H [NCIt concept]
- FBXW7 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- F-Box Domain [NCIt concept]
- WD Repeat [NCIt concept]
gene_product_is_element_in_pathway
- Cyclin E Degradation Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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