Preferred Label : F-Box Domain;
NCIt synonyms : F Box; F Box Domain; F-Box;
NCIt definition : The F-box consists of three helices. The H1 helix packs orthogonally with the H2-H3
antiparallel pair. The F-box domain is a 42-48 amino acid conserved domain found at
the N-terminus of F-box proteins. F-box proteins act as adaptor components of the
modular E3 ubiquitin ligase SCF complex that functions in phosphorylation mediated
ubiquitination. The F-box domain mediates interaction with Skp1, which links F-box
proteins to a core ubiquitin-ligase complex composed of Rbx1, cdc53/Cul1 and the E2
conjugating enzyme cdc34. The C-terminal region of F-box proteins are also composed
of various modular domain that interact with target substrates, often in a phosphorylation
dependant manner.;
Origin ID : C14103;
UMLS CUI : C1517104;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
