Transducin-Like Enhancer Protein 1

Preferred Label : Transducin-Like Enhancer Protein 1;

NCIt synonyms : TLE1; Enhancer of Split Groucho-Like Protein 1; E(Sp1) Homolog; ESG1;

NCIt definition : Transducin-like enhancer protein 1 (770 aa, 83 kDa) is encoded by the human TLE1 gene. This protein is involved in transcriptional regulation.;

NCIt note : Transducin-like enhancer protein 1 is a transcriptional corepressor, except when it acts as a transcriptional coactivator for estrogen-related receptor gamma. (UniProt);

Details

Origin ID

C104862;

UMLS CUI

C3541273;

OMIM relation
- Tle family member 1, transcriptional corepressor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- TLE1 Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleoplasm [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- WD Repeat [NCIt concept]
gene_product_is_element_in_pathway
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
- WNT Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Organogenesis [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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