WD Repeat-Containing Protein 5

Preferred Label : WD Repeat-Containing Protein 5;

NCIt synonyms : BMP2-Induced 3-kb Gene Protein; Cilia and Flagella Associated Protein 89; WDR5;

NCIt definition : WD repeat-containing protein 5 (334 aa, 37 kDa) is encoded by the human WDR5 gene. This protein plays a role in post-translational modification of histone proteins.;

NCIt note : WD repeat-containing protein 5 is part of the WD repeat-containing protein 5 Ada2a-containing (ATAC) histone acetyltransferase (HAT) complex and several histone methyltransferase complexes. (UniProt); WD repeat-containing protein 5 is a core member of the COMPASS histone H3 Lys4 (H3K4) MLL (1-4) methyltransferase complex. (Cell Reports. 2016; 16:133-147.);

Details

Origin ID

C132136;

UMLS CUI

C1610219;

Automatic exact mappings (from CISMeF team)
- WD repeat domain 5 [HGNC gene]
- Wd repeat-containing protein 5 [OMIM gene]
OMIM relation
- Wd repeat-containing protein 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- WDR5 protein, human [MeSH Supplementary Concept]
- WDR5 protein, human [MeSH concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- WDR5 Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- WD Repeat [NCIt concept]
gene_product_plays_role_in_biological_process
- Histone Modification [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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