Gasdermin-B - CISMeF

Preferred Label : Gasdermin-B;

NCIt synonyms : Gasdermin B; Gasdermin-Like Protein; GSDMB;

NCIt definition : Gasdermin-B (411 aa, 47 kDa) is encoded by the human GSDMB gene. This protein is involved in pore formation and pyroptosis.;

NCIt note : Cleavage of the peptide bond after Lys-244 of gasdermin-B by granzyme A (GZMA) relieves C-terminal mediated autoinhibition and releases the N-terminal moiety (GSDMB-NT; p30). The N-terminal portion binds to cell membranes and forms pores, which initiates pyroptosis. (UniProt);

Details

Origin ID

C188907;

UMLS CUI

C2352817;

OMIM relation
- Gasdermin b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GSDMB protein, human [MeSH Supplementary Concept]
- GSDMB protein, human [MeSH concept]
Validated automatic mappings to BTNT
- GSDMB protein, human [MeSH concept]
- GSDMB protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- GSDMB Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Antibacterial Response [NCIt concept]
- Cytolytic Process [NCIt concept]
- Pyroptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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