Pyroptosis - CISMeF

Preferred Label : Pyroptosis;

NCIt definition : An inflammatory form of programmed cell death characterized by caspase-dependent formation of plasma-membrane pores, which leads to pathological changes in osmotic potential that ultimately result in cellular lysis and release of pro-inflammatory cytokines. It occurs most frequently following infection with intracellular pathogens, but also has a role in tumor suppression and the initiation of anti-tumor immune responses, as well as in autoimmune and cardiovascular diseases.;

NCIt note : Pyroptosis is dependent on caspase-1 activation.;

Details

Origin ID

C114729;

UMLS CUI

C2610960;

Currated CISMeF NLP mapping
- Pyroptosis [MeSH Descriptor]
- Pyroptosis [MeSH concept]
- pyroptosis [GO term]
- pyroptosis [COVID-19 Thesaurus concept]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- Pyroptosis [MeSH Descriptor]
- pyroptosis [GO term]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_involves_gene_product
- Gasdermin-B [NCIt concept]
process_involves_gene
- GSDMB Gene [NCIt concept]
- GSDMB wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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