Multicilin - CISMeF

Preferred Label : Multicilin;

NCIt synonyms : Multiciliate Differentiation and DNA Synthesis-Associated Cell Cycle Protein; Multiciliate Differentiation and DNA Synthesis Associated Cell Cycle Protein; MCIDAS; McIdas Protein; Protein Idas;

NCIt definition : Multicilin (385 aa, 42 kDa) is encoded by the human MCIDAS gene. This protein plays a role in the transcriptional activation of genes involved in multiciliate cell differentiation.;

NCIt note : Multicilin plays a role in cell cycle regulation by forming dimers with geminin (GMNN). Formation of this dimer reduces the association of GMNN with DNA replication factor Cdt1 and promotes both pre-replication complex assembly and DNA replication.;

Details

Origin ID

C204001;

UMLS CUI

C3178722;

OMIM relation
- Multiciliate differentiation and dna synthesis-associated cell cycle protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCIDAS protein, human [MeSH Supplementary Concept]
- MCIDAS protein, human [MeSH concept]
gene_encodes_gene_product
- MCIDAS Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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