Nuclear Autoantigen Sp-100

Preferred Label : Nuclear Autoantigen Sp-100;

NCIt synonyms : SP100; Nuclear Dot-Associated Sp100 Protein; SP100-HMG Nuclear Autoantigen; Nuclear Body Protein SP100; Nuclear Antigen Sp100; Speckled 100 kDa;

NCIt related terms : Sp100 Nuclear Antigen;

NCIt definition : Nuclear autoantigen Sp-100 (879 aa, 100 kDa) is encoded by the human SP100 gene. This protein is involved in PML body function, transcriptional regulation and DNA binding.;

Alternative definition : CDISC: An antigen encoded by the SP100 gene and is involved in promyelocytic leukemia nuclear (PML) body function, transcriptional regulation and DNA binding. It can be considered as an autoantigen and is commonly associated with the autoimmune disease primary biliary cholangitis.;

Détails

Origin ID

C176845;

UMLS CUI

C5445273;

Automatic exact mappings (from CISMeF team)
- Nuclear body protein sp100 [OMIM gene]
- SP100 nuclear antigen [HGNC gene]
- sp100 [LOINC component]
OMIM relation
- Nuclear body protein sp100 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Sp100 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SP100 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- HMG-Box [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tumor Suppression [NCIt concept]

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