Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, Mitochondrial

Preferred Label : Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, Mitochondrial;

NCIt synonyms : NAD-Dependent Methylene Tetrahydrofolate Dehydrogenase Cyclohydrolase; MTHFD2;

NCIt definition : Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (350 aa, 38 kDa) is encoded by the human MTHFD2 gene. This protein is involved in folate metabolism.;

NCIt note : Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial has the following activities: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9). (UniProt);

Details

Origin ID

C104945;

UMLS CUI

C3540574;

Automatic exact mappings (from CISMeF team)
- Methylenetetrahydrofolate dehydrogenase 2 [OMIM gene]
OMIM relation
- Methylenetetrahydrofolate dehydrogenase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MTHFD1 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrion [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- One Carbon Pool by Folate Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Folic Acid Metabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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