Preferred Label : Myeloid Cell Leukemia 1 Inhibitor PRT1419;
NCIt synonyms : MCL1 Inhibitor PRT1419;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein myeloid cell leukemia
1 (MCL1; induced myeloid leukemia cell differentiation protein; myeloid cell leukemia-1;
Mcl-1; Bcl2-L-3), with potential antineoplastic activity. Upon oral administration,
the MCL1 inhibitor PRT1419 targets and binds to MCL1. This prevents the binding of
MCL1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis
of cells overexpressing MCL1. MCL1, an anti-apoptotic protein belonging to the Bcl-2
family of proteins, is upregulated in cancer cells and promotes tumor cell survival.;
Molecule name : PRT 1419; PRT-1419;
NCI Metathesaurus CUI : CL1642798;
Origin ID : C176964;
UMLS CUI : C5447522;
Semantic type(s)
- concept_is_in_subset
- has_target
