" /> Tapotoclax - CISMeF





Preferred Label : Tapotoclax;

NCIt definition : An inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. Upon administration, tapotoclax binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.;

UNII : 97W7N9T08G;

InChIKey : JQNINBDKGLWYMU-GEAQBIRJSA-N;

CAS number : 1883727-34-1;

Molecule name : AMG 176;

NCI Metathesaurus CUI : CL507931;

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27/07/2025


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