NCIt definition : An inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid
cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. Upon
administration, tapotoclax binds to and inhibits the activity of MCL-1. This disrupts
the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces
apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2
family of proteins, is upregulated in cancer cells and promotes tumor cell survival.;
UNII : 97W7N9T08G;
InChIKey : JQNINBDKGLWYMU-GEAQBIRJSA-N;
CAS number : 1883727-34-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1883727-34-1
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