Preferred Label : BCL2 Inhibitor VOB560;
NCIt synonyms : Bcl-2 Inhibitor S65487;
NCIt definition : An inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential
pro-apoptotic and antineoplastic activities. Upon intravenous administration, Bcl-2
inhibitor VOB560 binds to and inhibits the activity of Bcl-2, thereby restoring apoptotic
processes in tumor cells. Bcl-2 protein is overexpressed in many cancer types and
plays an important role in the negative regulation of apoptosis; its expression is
associated with increased drug resistance and tumor cell survival.;
Molecule name : S 65487; S-65487; VOB-560; VOB 560;
NCI Metathesaurus CUI : CL938051;
Origin ID : C158510;
UMLS CUI : C5554558;
Semantic type(s)
- concept_is_in_subset
- has_target
